AstraZeneca vs. Pfizer: Comparison Chart Summary While both AstraZeneca and Pfizer are among the top contenders in the ongoing COVID-19 vaccine race, the Pfizer vaccine is proved to be the most effective with an unmatched efficacy rate of almost 95% compared to AstraZeneca’s 63%. ), Thus, the first data on the relative success of these two vaccines is of substantial interest as many people in the UK ask – although they have no choice – ‘which should I have?’, As with all these studies, although this is a publication from the government agency – Public Health Scotland (PHS) – it has not been peer reviewed and we should treat the results as preliminary, The question they asked was a simple one:“, Unlike the recently published preliminary studies from Israel, this study was based on a stronger epidemiological approach, They studied data from the entire Scottish population, It is having access to the whole population that makes this study so powerful, Their access to general practice data allowed them to identify individuals who had, and who had not, been vaccinated – the dark green boxes, They identified all people who had been in hospital with Covid-19, but only included those cases who had a positive PCR test – the light green boxes, They then compared the rates of being admitted between people who had and had not been vaccinated – the red and purple bordered light green boxes, The area where they lived in terms of deprivation, Plus they were able to allow in part for the fact that those who were vaccinated were more likely to be health or care workers and hence more exposed to becoming infected, They then determined the success of the vaccine programme by working out how far fewer were the number of cases who had been vaccinated compared to the non-vaccinated, They compared the numbers in the red bordered boxes with those in the purple bordered boxes, Thus, if there were only half the risk of PCR positive hospitalised cases in the vaccinated group to that in the vaccinated group, this was a vaccine efficacy of 50%, In doing these calculations they took into account the other differences between the 2 vaccine groups listed above (eg age etc), As the research assumed vaccine efficacy would increase with the more days after the first dose, they compared the efficacy of the vaccines at the different time periods, All the data refer to the success of the vaccine in terms of days after the first dose, Compared to those who had not been vaccinated,  there was a reduction of around 40% in those who had Pfizer and 70% in those who had had AstraZeneca in the second week (7-13 days) after the first dose, By 5 weeks (28-34 days) both vaccines were increasingly effective at reducing the number of cases – by over 85% in those who had the Pfizer and 94% in those who had the AstraZeneca, As mentioned above, these are preliminary data and have not been peer reviewed, Both vaccines, as everyone knows, are designed to be given as 2 doses, but that will only increase their success, The data refer to hospitalised cases only and may not reflect how the vaccines work at preventing mild or asymptomatic infection, Two thirds of those vaccinated were over 65 and almost 20% over 80, so answering the question about success in the elderly, Most cases were of the new ‘English’ variant* whereas the trial data were collected before this variant was widespread, Who got which vaccine was likely to be random, as this was determined by the logistics of the vaccination programme, They could take into account the background differences in risk of severe Covid-19 between those in Scotland who had or had not been vaccinated by the time of this analysis. The White House on Monday told reporters that … I live in Australia where I was given my first shot of Astra this morning. Because the overall background infection risk may have been different in the volunteers in the trials, The way that the 2 studies were designed meant that they had different ways of identifying the cases of Covid-19 that emerged during the follow up, Nonetheless further support for Pfizer’s success came from the results from Moderna vaccine – an almost identical vaccine to the Pfizer – which produced the same very impressive reduction, AstraZeneca also had not included many elderly people (aged over 65) in their trial, and this lack of data – in the population most at risk of serious consequences from the infection – raised concerns that the AstraZeneca vaccine might not be effective in older people, On the back of that concern, many European countries in high profile declarations, suggested they would not be using the AstraZeneca vaccine, Further, recent data from a study in young South Africans showed the AstraZeneca vaccine did not reduce mild to moderate infection: the trial was abandoned and the South African government threatened to return their supply of the AstraZeneca vaccine, This concern was fuelled by the emergence of the new South African variant, which was responsible for the cases in that study, The UK is currently the only country routinely using both the Pfizer and AstraZeneca vaccines in any number, In all 4 nations of the UK, who receives which vaccine is determined by logistics issues and vaccine availability and patients have no choice, (For interest my wife and I had our first doses just 3 days apart at the same centre, she had Pfizer, I had AstraZeneca! The vaccines need to be administered in two doses set three weeks apart. newspaper archive. London: One in four people experience mild, short-term systemic side effects such as headaches, fatigue, and tenderness after receiving the Pfizer or AstraZeneca vaccine, according to a new study published in Lancet Infectious Disease. “That’s the whole point, that you have to look at both sides and say: ‘How big are the benefits in relation to the risks?’”. How do I know if I have a blood clot in my leg? At Thursday’s Downing Street press briefing, Boris Johnson urged people to take the AstraZeneca vaccine if they are offered it, to help protect them against Covid-19. The MHRA approved the Pfizer vaccine as the first Covid vaccine to be rolled out in the UK last year, and since then millions of people have received it. Where is the AstraZeneca vaccine made in the UK? They then show this protein to the body's immune system so it can produce the cells needed to destroy any foreign organism displaying it. See more stories on Insider's business page. Not only has the AstraZeneca vaccine been found to be safe, but data also shows the vaccine is highly effective at protecting people against Covid-19. When you subscribe we will use the information you provide to send you these newsletters. If you would like to receive email notifications of new posts on this blog just click this link and enter your email at the bottom of the home page: https://makingsenseofcovid19withs.com. 0 0 2 minutes read. 2021 Making sense of CoVid-19 with Silman, on Pfizer vs AstraZeneca vaccine: first comparative data, New Israeli data show good protection after one dose of Pfizer vaccine. Pfizer vs AstraZeneca safety explained, Is the Pfizer vaccine safe? Thank you Alan as ever for your detailed and up-to-date analysis. Both the Pfizer and AstraZeneca vaccines need two doses to be effective, with the Pfizer option needing to be given 21 days apart and the AstraZeneca jab 4-12 weeks apart. Sometimes they'll include recommendations for other related newsletters or services we offer. Italy and Germany to resume 'safe' AstraZeneca jab, UK vaccine booster: New jab rollout in in autumn due to Covid variants, Britons furious as VDL shot down over 'ridiculous' vaccine war on UK, Covid vaccine data MAPPED: London lagging almost 10 percent behind, EU officials to get vaccines in exclusive centres, AstraZeneca IS safe and effective! Reading from a paracetamol packet’s datasheet, Professor Van-Tam said: “The rare side effects are allergic reactions such as skin rash, mouth sores, fever, difficulty breathing, [being] more prone to bleeding, bruising, fever, infections, nausea, sudden weight loss, loss of appetite, jaundice, yellowing of the eyes and skin. Millions of UK recipients have received either the Pfizer or AstraZeneca vaccine to date, which have both shown to offer significant protection from Covid-19. The European regulator added it "cannot rule out definitively" a link between "a small number of cases of rare and unusual but very serious blood clotting disorders" and the vaccine, though investigations are ongoing. Yesterday (22nd February) the Scottish Government published preliminary data from their first 1.1 million people who had been enrolled in the national vaccine roll out programme. What did we know before this Scottish Study, *See post: https://makingsenseofcovid19withs.com/2020/11/22/how-do-dna-and-rna-vaccines-work/, *There are too few cases so far of the other variants for any of the vaccines to provide robust data, At this stage there is strong reassurance that the two vaccines are both very effective at preventing serious infection after one dose and no suggestion that the AstraZeneca vaccine is any less effective. Predicting when the pandemic will end: the role of super-spreaders? ", DON'T MISS: Britons furious as VDL shot down over 'ridiculous' vaccine war on UK [ANALYSIS]Covid vaccine data MAPPED: London lagging almost 10 percent behind [MAP]EU officials to get vaccines in exclusive centres [INSIGHT]. J’espère que vous êtes que tous les deux en bonne santé ! Dose of Sputnik V and Pfizer – Pfizer vaccine shots are administered as intramuscular injections as a series of two doses, 0.3 ml each. Our Privacy Notice explains more about how we use your data, and your rights. Like the AstraZeneca vaccine, the Pfizer/BioNTech Covid vaccine has also passed rigorous safety checks in the UK. The Pfizer-BioNTech COVID-19 vaccine has a 95% efficacy rate; Moderna's vaccine offers 94% protection against the virus; AstraZeneca has been approved for use in the U.K. with 60% effectivity ( Log Out /  The SEVEN key symptoms, Does Pfizer vaccine cause blood clots? AstraZeneca pledged the vaccine would cost just a few dollars per dose and be sold without making a profit, whereas Pfizer's vaccine costs $18.40-$19.50 per dose. https://www.fool.com/.../07/better-coronavirus-stock-astrazeneca-vs-pfizer Home of the Daily and Sunday Express. Three Covid vaccines from Pfizer/BioNTech, Oxford/AstraZeneca and Moderna have been approved for use in the UK so far. “Those are documented rare side effects of paracetamol, but we all understand the benefits of them and this is no different a situation.”. Thanks. Change ), You are commenting using your Twitter account. Boris says he's getting AZ jab tomorrow as he lashes out at EU ban. Covid vaccines have to pass extensive safety checks before they are approved in the UK, AstraZeneca vaccine: UK regulator issues warning about headaches, Is the Pfizer vaccine safe? Merci beaucoup! See today's front and back pages, download the newspaper, UK vaccine shortage: Why does the UK need to 'retest' Covid vaccine? Antibody responses lasted at least 10 weeks for both vaccines, the study found. EMA tells Europe to END suspension. According to the NHS, millions of people have been given a Covid-19 vaccine and reports of serious side effects, such as allergic reactions, have been very rare and no long-term complications have been reported. Fill in your details below or click an icon to log in: You are commenting using your WordPress.com account. However, the European Medicines Agency (EMA) has now concluded the AstraZeneca vaccine is "safe and effective". Just for comparison, the Novavax vaccine is showing over 95% protection overall now in trials and way over 90% protection for all variants, including the Kent, Brazilian and South African mutations. You can unsubscribe at any time. To get a person's body to recognise the virus, both the AstraZeneca and Pfizer vaccines use the body's own cells to produce the spike protein. Professor Van-Tam said: “All medicines have side effects and all medicines have benefits. AstraZeneca have COVID-19 vaccines in late-stage clinical trials around the world. Effectiveness rose to 72% against COVID-19 with symptoms in the UK survey of about 375,000 people. These data are the first real world information on whether there are any differences between the success rates from these 2 vaccines. The number one question that people in the UK when chatting to each other in the past few weeks is “Which vaccine did you have?”! Three Covid vaccines from Pfizer/BioNTech, Oxford/AstraZeneca and Moderna have been approved for use in the UK so far. ( Log Out /  Boris Johnson urged people to take the AstraZeneca vaccine if they are offered it at this week's Downing Street briefing. ( Log Out /  Covid-19: USTR holds talks with Pfizer, Astrazeneca over increased vaccine production, IP rights waiver. The first dose is for recognizing the virus and getting your immune system ready for the virus, and the second dose enhances your immune response. AstraZeneca vs. Pfizer vs. Moderna COVID-19 Vaccine 02/09/2021 Bluegrass Direct News AstraZeneca, COVID19, Moderna, Pfizer, vaccine AstraZeneca’s COVID … Very common side effects, which may affect more than one in 10 people who have the Pfizer vaccine, include: England’s deputy chief medical officer, Professor Jonathan Van-Tam, used a packet of paracetamol to demonstrate all medicines have side effects at a recent coronavirus briefing at Downing Street. ( Log Out /  Data from the ZOE Covid Symptom Tracking Study showed fewer people experienced mild side effects from AstraZeneca and Pfizer's vaccines than had been suggested in clinical trials. Pfizer gave 95% protection against being ill with 2 doses 3 weeks apart; AstraZeneca gave a lower protection but this could reach 85% with 2 doses 3 months apart *See post: https://makingsenseofcovid19withs.com/2020/11/22/how-do-dna-and-rna-vaccines-work/ Other challenging news for AstraZeneca Change ), You are commenting using your Google account. However, most of the side effects reported in clinical studies were “mild to moderate” in nature, according to the Government’s vaccine guidance. It is not possible to compare the results of two trials done in different populations at different times – why not? A single dose of Pfizer-BioNTech of AstraZeneca-Oxford University COVID-19 vaccine reduced infections by 65% in a UK survey of about 275,000 people. They do this in slightly different ways*: Pfizer by providing the genetic instructions – mRNA – to make the spike protein, AstraZeneca by providing an earlier stage of the same genetic instructions which are bolted onto to a harmless virus to then make the spike protein, By targeting the same spike protein, indeed the same genetic version of the spike protein, in theory both vaccines should be equally successful, The key clinical trials before the vaccines were licensed however showed that, Pfizer gave 95% protection against being ill with 2 doses 3 weeks apart, AstraZeneca gave a lower protection but this could reach 85% with 2 doses 3 months apart, These headline differences in the results between these trials seemed to suggest that Pfizer might be superior. As well as helping to protect people against serious illness and death from coronavirus, it is hoped widespread vaccine rollout will help to ease lockdown measures in the UK and allow life to return to normality. The Oxford/AstraZeneca vaccine was subject to rigorous testing for safety before it was approved by the UK regulatory body, the Medicines and Healthcare products Regulatory Agency (MHRA). One dose of a Pfizer-BioNTech or AstraZeneca-Oxford jab cut COVID-19 infections by 65% in a study. xxx. Reading this my Astra doubts at rest somewhat. This programme, like the rest of the UK, involved using both the Pfizer and AstraZeneca vaccines. In recent weeks, several countries in Europe have suspended the use of the AstraZeneca vaccine, pending investigations into whether the vaccine causes blood clots. The Australian Government recommends everyone aged six months and over get immunised against seasonal flu. So, if the first dose is on Day 1, … Express. https://www.fool.com/.../09/better-coronavirus-stock-astrazeneca-vs-pfizer Health Secretary Matt Hancock said earlier this week of both the Pfizer and AstraZeneca vaccines: “After a single dose of either vaccine, protection against Covid-19 is around 60 percent, that's protection against getting it, protection against hospitalisation is around 80 percent and protection against death is around 85 percent. Millions of UK recipients … I shall be sending this on to friends in France who perhaps are following Monsieur Macron too closely! (Reuters: Gareth Fuller/Andreas Gebert) Scientists at Oxford University have released more data that confirm coronavirus vaccines made by Pfizer-BioNTech and AstraZeneca both significantly cut the risk of infection after a single dose. Both the Pfizer and AstraZeneca vaccines induce immunity but in different ways. Change ), You are commenting using your Facebook account. 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