At doses used to treat diarrhea, this drug will cause neurological toxicity in dogs with the MDR1 mutation. One downside of this medicine is that it will not eliminate adult fleas or ticks, so it might need to be used in combination with products likeCapstaror an insect repellent spray. Water-fast after 48 hours. I gave a mini aussie and a minnie aussie/border collie mix. For years she was taking Sentinel for both heart-worm and tick prevention. Fleas this summer in my part of CA are particularly bad. It has the same active ingredients as Seresto (plus one), so a bit stronger. Frontline Plus targets four kinds of ticks, fleas (including eggs and larvae), lice, and mites that cause sarcoptic mange. Happy to help! Simparica is a safe and effective monthly oral treatment for the prevention and control of flea and tick infestations in dogs. Also what can be used for giardia? I would appreciate your comments on Advocate. I honestly didnt know they existed until I started researching more to answer your question. There werent as many seizures reported as with Nexgard, but it did have several more reported than Bravecto. Im trying to find out if this is safe for her. Any thoughts on either of these? After 24 hours, it is considered waterproof and a bath, while alleviating some effects, will not offer as much relief. Simparica TRIO (sarolaner/moxidectin/pyrantel) is a flavored chewable tablet for administration to dogs 8 weeks of age and older. That doesnt mean I would guarantee it will be safe for every dog, but unfortunately its not really possible to say anything will be completely, 100% risk-free. Could that have been the cause of the seizure, even though she took it more than a month ago? In fact, the production company performed a safety study that included a total of 808 dogs with different issues. (Your vet or a pet store associate may recommend otherwise, but bear in mind that they also want to make money.). This product should only be used in dogs and puppies over 8 weeks and who weigh more than 2.8 pounds. The FDA approved Nexgard for flea treatment in dogs in September 2013, Bravecto in May 2014, Simparica in February 2016, and Credelio in January 2018. But Ive given it a caution designation as it should not be given in combination with heartworm meds and is not safe for dogs who are at risk for seizures. The FDA thinks this drug is safe to use on your dog. Based on its limited coverage of external parasites, cautionary potential side effects label, and its non-endorsement for pregnant or nursing females, I decided I could do better for my dogs. Thanks. Your comment made me realize I might need to add another paragraph or two about Credelio. Basically, while the FDA has not pulled these drugs from the market, it has asked the product manufacturers to add precautions to their labels while it continues to monitor information submitted by veterinarians, the companies themselves, and individual product users. Also, it is not recommended for use with other medications. I was leaning towards, but have not tried, the combination of Interceptor tablets (heartworm) + Credilio (flea and tick) tablets. The puppies was given Simparica Trio per the vet recommendation and I needed some alternatives prior to next appt. I have 7 collies and I am reluctant to put them on anything thats not natural , we did get a kitten and found a flea so looking for something to treat all as a precautionary for a month as we are in winter season in Northern Ontario Canada. Its a nice alternative to Vectra 3D since its not as potent (so less chance for irritation), yet it also has some repellent properties. Children should be kept away from the dog for 2 hours until the liquid has had time to dry, and be sure to wash your hands after application. (This is for all dogs, not just for dog breeds at-risk for MDR1.) Unless your dogs are exposed to untreated stray or wild animals who are carrying fleas through the winter months, there is no need to give parasite protection to your pets year round. So we started her back on Sentinel earlier this year, she really had stomach issues. My dog was under the 6 month mark that most dogs start idiopathic epilepsy, he could not have had a history. Sugar is almost 4 months old now! If you choose to use Advantage Multi, great care should be taken to only apply the liquid between your dogs neck and shoulder blades, where it cannot be reached by licking. Pet owners will have . While my pain levels went down, I noticed that my heart rate went up! Its worth making a phone call to see what they would recommend for your pup. I can live with that. Have you reported the seizure to Bayer (the company that makes Seresto collars) and to the EPA? Our are both indoors and outdoors. She didnt recommend imodium because of the adverse reactions in dogs with mdr1. A mutation of this gene causes sensitivity to Ivermectin and a number of other drugs. Thank you for the positive feedback. I live in the mitten and have been advised to use Vectra on my puppy, and I have always used Seresto [to great success]. Though all of these medicines had previously been approved by FDA scientists, now data received by the agency indicates that some animals receiving Bravecto, Nexgard, or Simparica have experienced adverse events such as muscle tremors, ataxia, and seizures.. The vet thought he would be nice and put Advantage Multi on our cats. I tried Seresto with my girl and she had a seizure. Thank you so much for all your hard work and care given to writing this very informative and extremely important study greatly appreciate it , I would like to thank you for your very thorough but get to the point info of all these parasitic treatments We have a rough Collie I could not find any info on safe treatments without wading through a river of muck. It makes me nervous since I have seen/read plenty of negative things about bravecto and Im also worried to combine bravecto with interceptor. I quoted a specific veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together. Thank you for your article. , Emily, thanks for a very helpful and informative article. In hot, flea-infested areas like where I live in Florida, Parastar Plus might not be the best option; but its definitely something I would have tried when I still lived in Michigan. I say this as she is running around the room l barking and trying to dig up the coachyep, just about nap time, That is excellent news, and Im so glad to hear it! So tick protection is also a must for us. Thank you! According to Dr. Jean Dodds of Hemopet, researchers and veterinarians thus far cannot point to breed characteristics, age group, drug interactions or genetic mutations as contributing factors to the latest findings that prompted the FDA warning. In other words, the reported adverse reactions to Bravecto had nothing to do with whether or not a dog had MDR1. We do, however, have lots of deer ticks (also known as black legged ticks). After Simparica is given its activity against ticks and fleas lasts for at least 5 weeks. Here are a few of the safest flea treatments for dogs on the market today and some of their pros and cons. If you have more than one dog and they engage in mutual grooming, you should probably pick a different parasite preventive. Please help! I chose Frontline Plus for him as it seems to be an older, safer spot-on. I was unaware of MDR1 Mutation drug reactions at the time. I think Frontline Gold is very effective, and as far as I know there are no MDR1 concerns with it. We do eat it! It probably is the safest as it is aimed only at preventing heartworm. Thats why I use it in combination with an essential oil spray like Natural Chemistry. She was obviously in discomfort. Prior to administration of ProHeart 12, dogs should be tested for existing heartworm infections. From the standpoint of MDR1 dogs, it is safe. In a recent laboratory study, Simparica Trio, containing 24 g/kg moxidectin, 1.2 mg/kg sarolaner and 5 mg/kg pyrantel, and Heartgard Plus and Interceptor Plus (n = 6) were administered in six consecutive monthly oral doses at the labeled dose rates after receiving an inoculation of 50 ZoeLA strain D. immitis L3 on day 30 [].Dogs were necropsied approximately 9 months post-inoculation and . Sugar is a great name for a Collie as they really are such sweethearts. I appreciate the research in this thank you! Wash hands after handling the product. Now we are out thousands of dollars when every event has been triggered by Simparica Trio. However, in such sensitive breeds (which may include, but not necessarily limited to, Collies and related breeds), the recommended dose should be strictly observed. I recently adopted a Collie puppy who came with a dose of Credelio and Interceptor, which I have in the past successfully used on my other 3 dogs (both Collies and the Aussie mix). My Collie is double MDR1 mutant. Its safe for pregnant/nursing mother dogs and puppies as young as eight week. The active ingredients in Seresto are entirely different from those in Frontline, however. Plus, Simparica's protection lasts for five weeks (35 days), and it does not decrease at the end of the month. Dinotefuran in particular is a strong pesticide, and all 3 of those ingredients combined are harsh on sensitive skin. Super useful research. Thanks Emily! We had a wonderful smooth girl for years and while many of the medication names here sound familiar, I cant remember what we gave her. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. Excellent research and well written article! I been debating which one to use on my BC and small BC mix for ticks as well as prevention of Mites, which seem to increase in numbers with the ever increasing number of Coyotes we see these days. Adverse Reactions. The product was well tolerated in dogs with a deficient multidrug-resistance-protein 1 (MDR1 -/-). Simparica (sarolaner) Chewables are safe, monthly flea and tick protection for dogs that start working fast and remain effective all month long. I went back and edited my comment for consistency. My Aussie/Pyrenees mix has had no issues with it, for instance. After a single administration of 5 times the maximum recommended dose to this sensitive dog breed, transient (MDR1 -/-) following single oral administration at 3 times the recommended dose. Another safe heartworm medication is the daily dimmitrol. Im going to order some of the organic spray to help. Best of luck to you and Sugar! The effectiveness of ProHeart 12 has not been evaluated in dogs less than 12 months of age. Eating poison. I think this is a couple years old. However, it would be best to have a veterinarian collect a skin scraping to examine under a microscope and determine whether skin irritation is caused by demodectic or sarcoptic mites, as the causes and treatments differ between the two types. Frontline Shield has Permethrin and Pyriproxifen, so my concern would be that those 2 ingredients together would be stronger and potentially cause skin irritation. I used Interceptor last year with no issues. It sounds similar to a couple other natural oil products Ive tried. Thank you for fostering! Rich Soil gives this excellent explanation of what DE is and how it works: the fossilized remains of marine phytoplankton. My pleasure! I had started my GSD on Revolution, but really always liked Frontline better and since that seems to cover more ticks and still protect us from unwanted mites I probably will lean toward that. Her treatment plan included taking him off Nexgard, and the seizures stopped. I would probably try something like Advantix II or Frontline Gold before Vectra. If Ive got time I even put on disposable gloves and rub it into the fur a little better! Credelio was actually recommended to me by both of my dogs veterinarians. I was using Seresto collars and am on the hunt for something else. Thank you so much for writing this article!!! Each tablet is formulated to provide minimum dosages of 1.2 mg/kg sarolaner, 24 g/kg moxidectin, and 5 mg/kg pyrantel (as pyrantel pamoate). According to a thorough study conducted on MDR1-affected dogs, Interceptor and its more affordable generic, MilbeGuard, rank high in ML safety due to their use of the compound called milbemycin oxime. Somewhere I read that its good for 4 kinds. Parastar Plus is not something Ive personally used, but it should be safe as one of its active ingredients is Fipronil (which is in Frontline) and the other active ingredient, Cyphenothrin, is in the same family of drugs as Permethrin. That is my concern. All the available heartworm medications on the market are a variation of what is known clinically as a ML (macrocyclic lactone) compound. Simparica is a flavored chewable solution for fast and effective treatment against fleas and ticks. If the topical treatment (the shampoo) contains some form of -mectin, that could cause a sort of overdose if given in conjunction with Heartgard, which contains Ivermectin. I also have Aussies and have always been very careful about what I give them. Safe for dogs from 1.25 kg; Can be given with our without food; Pork liver flavoured chewable tablet; Safe in heartworm positive dogs; Safe in avermectin-sensitive collies and dogs with the MDR1 gene; Heartworm. Before I got them home, they went into comas. Unfortunately, it seems most people who lost their dogs to Seresto collars simply did not make the connection until it was too late. I did some digging, and from what Ive read it sounds like just one report would be considered anecdotal and would not be considered evidence that Seresto could cause seizures, but if there are 2 or more reports then the company might be obliged by the EPA to add a potential seizure warning to its label or possibly to do more clinical safety research. Unless youre, say, an expat living in China, you can definitely find a better option. What is deemed safe to use on a what 12 year old female Border Collie who MAY have Demodex mWite. If youre going the oral tablet route, Credelio is one I personally feel comfortable with! However, the medicine can be passed through a mothers milk: so it is not recommended for pregnant or nursing female dogs, though it is safe for puppies 8 weeks of age and older. Mary. Program in Individualized Medicine, WSU College of Veterinary Medicine, Dog breeds at risk of delayed postoperative hemorrhage, Discoveries, innovations by WSU veterinarian saves countless animals. Dash is MDR1 mutant/normal. They were extremely helpful people. After talking to a variety of Collie people, Frontline seems to be the most trusted of the topical flea/tick products available. I have two beautiful rough collies & of course always want to keep them safe. One thing about Credelio is that it only breaks the flea life cycle at one point (kills adult fleas only after they bite the dog), so you may want to use a natural flea & tick repellent spray to increase its effectiveness. The more common complaint with Frontline Plus is that its not strong ENOUGH for a lot of people, since it lacks repellent properties. No one knows yet why some dogs react to isoxazolines like Simparica and others dont, and theres no way to know until its tested on an animal. Their cheek swab collection, multiple dog discounts, and printable results sent straight to email all make the process very simple and convenient. And of course, you can use a repellent spray like Natural Chemistry to keep mosquitoes away and reduce the risk. Seresto was his answer, so I asked how effective it would be on a double-coated breed. Trish. ? I myself have successfully used both on my 2 Collies and my Aussie mix with no ill effects. No adverse effects were observed. Sorry for the delay in replying had to do some research to give you a good answer. Kudos to you for going out of your way to manage your Collies health, and good luck as you continue to search for what will work best for her! I interviewed a few people (rescue workers, owners, and breeders) from that group for this article I wrote about Border Collies. One observation: You mention that Credelio has fewer reported seizures (6 in as many months) than other drugs in the isoxazaline class. They said Frontline Plus doesnt really work anymore like it used too. We actually live in New Hampshire and hike (off-leash) quite frequently. Ive been accused of being overly cautious when it comes to my dogs, but I admit to being a better safe than sorry kind of person! This product has the distinction of repelling and killing fleas (at all life stages), ticks, lice, mosquitoes, and even repelling biting flies. Use with caution in dogs with the MDR1 mutation for the same reason. I doubt it as he was on leash and Im always watching him. It is approved for use on puppies at least 3 pounds in weight and 7 weeks of age, cats, and even ferrets. GSD is an abbreviation for German Shepherd Dog , Thankyou so much for your articleso much great infoI have a 7 month mini Aussieon Symparticabut not feeling good about itshe hasnt been tested for MRD1 but I know I have to change it upthankyou again , Youre very welcome, and good luck with your pup! The agency is asking the manufacturers to make the changes to the product labeling in order to provide veterinarians and pet owners with the . The collar releases no odor or residue, comes with a quick release catch to prevent accidental choking, and even has safety reflectors. Frontline Plus is milder than Frontline Gold, which I wouldnt recommend for the same reason that I dont like recommending Advantix theyre too strong and have a tendency to cause skin reactions. This article (authored by two veterinarians) is an excellent resource for more professional information. The drawback of Advantage is that it does not offer any protection against ticks. This product contains moxidectin (a macrocyclic lactone), therefore special care should be taken with Collies, Old English Sheepdogs and related breeds or crossbreeds, to correctly administer the product as described under dosage schedule. enough to have 4 dogs like I do! Share the results with your veterinarian to let them know to avoid or adjust the dose of certain medications. . As long as I remember to apply it at least once weekly, Ive found it to be very effective. As far as which flea and tick protection would be safest for a puppy, some of my top picks are Capstar (for instant relief, not necessarily long-term use), a natural oil spray like Natural Chemistry or Wondericide, or something not very harsh like Frontline Plus. So, what do you think of Parastar Plus? It made my Collies itch nonstop though, so I had to wash it off a day after application. Thank you for writing this article. As one holistic veterinarian explains: The Vectra 3D can have side effects which include extreme restlessness and jitteriness, described as anxiety or manic behavior. Coming from the house of Zoetis, Simparica is an efficient flea and tick treatment providing a gamut of benefits to both dogs and pet parents. In the meantime, no need to give heartworm meds if its still snowy where you are, so youve got some time to figure out what to do before the mosquitoes become active again! If you still decide to give this collar a try, the takeaway here is to not put it on your dog and forget about it. (Just bear in mind that Preventic contains amitraz, which is toxic to cats.). I just took her off Sentinel Flavor Tabs. However, I officially can no longer recommend Seresto collars, since it is now known thatthey have caused seizures and death in dogs and even some reactions in humans who sleep with their dogs in their beds. Im not a veterinarian and would of course recommend that you consult with yours, but I do think that dogs vary individually (just like people) and can react differently to certain medications. Thank you for the warning. Of course, I do have to state the disclaimer that theres no guarantee with any product that it wont cause a reaction, but it sounds like youre doing a good job of monitoring your girl after giving her anything. Do you know what the ingredients are in the medicated shampoo? (I have to give them baths with a very mild or medicated shampoo.) In FL resistance is bad, and we split our time between FL & NJ. I have never even heard of the latter and do not believe they exist in Canada. Interceptor and Sentinel are safe for Border Collies. Our vet recommended Bravecto because he said it had been specifically tested on dogs with the MDR1 gene. Regardless of the heartworm product you choose, as the Institute of Pharmacology and Toxicology says, treatment of MDR1 mutant dogs with macrocyclic lactones in general requires particular caution. It really boils down to weighing the benefits of medications against the risks from internal parasites. For instance, some MLs are best tolerated when orally ingested, which meant that a pill form of that particular compound was developed; but moxidectin was just the opposite. No toxicity was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one year. Thank you thank you thank you for this article. As noted in an article by Dog Aware:Advantage Multi, which combines imidacloprid for flea control with moxidectin for heartworm prevention, was found to cause no side effects when applied topically to affected dogs even at 5 times the recommended dose, but ingesting less than half the recommended topical dose caused extreme toxicity leading to coma in four of five dogs.. I like to sprinkle some around the perimeter of my yard and lay an inner circle around the edges of my house which probably looks like Im trying to keep out evil fairies and other fantasy creatures. The best thing about Seresto is how long it can do its job up to 8 months! Please let me know how the Wondercide works for you! When fleas or ticks bite the dog, they are exposed to the drug and killed during their blood meal. The FDA determined Heartgard is safe for dogs with the MDR1 mutation when used at label doses. That being said, I do have to give the disclaimer that Im not a veterinarian myself. Those are both still very effective products, but have fewer horrror stories of terrible skin reactions. I give Interceptor Plus for HW, but Im conflicted about which direction to go for flea & tick. I have two Miniature Australian Shepherds that are my entire world: Nola Riley and Otis Kai : ) Nola is MDR1-Heterozygous. Congratulations on your new puppy. It can be used to destroy bedbugs, cockroaches, ants, and even fleas. My vet wants to give him a vaccine (?) According to the product description, side effects as a result of Trifexis are rare, but can be as severe as seizures or even a coma. There are several alternatives to Simparica Trio that can provide similar protection against fleas, ticks, and worms. Unfortunately, when we gave Vakaa his dose of Credelio, he threw it up twice actually since I wasnt able to get to him before he gobbled up some of his regurtitated food! We have an MDR1 heterozygous Aussie and this was the best breakdown of the meds we found. If your dogs arent reacting to it, why are you switching? Last time I took my Collies to a pet store here in parasite-infested Florida, I asked one of the clerks what they sold the most of as far as flea and tick preventives. for, I think its brown ticks. She had a severe reaction with diarrhea, drooling, depression etc. Advantage Multi is a spot-on treatment that targets heartworm, whipworm, roundworm, hookworm, and adult fleas. Thank you!! If you click on combination medications in the table of contents at the beginning of the article and read the section on Advantage Multi, youll find that Ive given it a caution rating along with reasons for that rating. Given at the proper doses and under the supervision of a veterinarian, ivermectin is safe for most dogs and is very effective in treating and preventing a number of parasites. (The Environmental Protection Agency is responsible for approving external flea and tick products.) (For those who may be wondering, the mutant/normal designation means that a dog carries one copy of a gene and is a carrier, though not affected to the degree that a homozygous, or mutant/mutant, dog would be.) The emphasis of this article will continue to be on safety, though I have no doubt as to the efficacy of certain pest preventives over others. Either way, I certainly dont want to risk it for him again. The most common adverse reactions in clinical trials were vomiting . If youre concerned about a possible hormonal imbalance being triggered by Effifax, it might be worth looking into an alternate flea control product that does not contain Fipronil. For those of you who want proof or a more in-depth explanation of whyIve given each medicine its label, feel free to read the commentary under each product and even follow the embedded links for further reading. You should still keep an eye on your pet when introducing new organic products. I follow this advice, since Im a safe-is-better-than-sorry person. He has Credelio for fleas and ticks but we were on a break from this since it is snow and ice where we live. Miscellaneous Some of these alternatives include: . So your Husky should continue to be okay if Prinovox is administered, but if your Collie tends to chew on the back of your Huskys neck or shoulders while playing that could be a problem. Dogs with the MDR1 mutation are not at increased risk for adverse effects. Nothing could be done for them. I am currently fostering 3 rescued puppy mill border collie females with sarcoptic mange. The following list shows the common dog breeds most likely to have the MDR1 mutation, and the percentage affected in each. But of course, do talk to your vet and see what they know. What do you know about this? Thank you for this. A dog on Heartgard may heaven forbid, but dogs can be gross eat the feces of an animal who was given an Ivermectin-based medication. Thanks for reply. Ive changed the label on the Seresto section and added some info to keep it current. Best of luck! Simparica is for use only in dogs 6 months of age and older. ATLANTA Thousands of dog owners worldwide blame a popular flea killer for harming their pets. Other drugs include Immodium and some chemotherapy drugs; there are others. I just dont know what to do about heartworm treatment and wonder if Interceptor instead of Interceptor Plus would be a better option or more of the same. In light of this, Im categorizing all three of these oral flea/tick protection chews as use with caution, although in fairness I must note that a link between the occurrences and seizure-prone or MDR1 dogs has not been identified. After being ingested by a dog, sarolaner is distributed throughout the body. The back label warns that it may be fatal for cats, and advises cats and dogs should be kept apart for 24 hours following application. I personally prefer something gentler as many Collies can have sensitive skin, but it really depends on the dog. Im glad you found this information helpful. is it safe or not to use it? Thank you for your very informative article. (Of course, skin irritation can happen with any topical product.) Thanks again for your time : ), Thank you for pointing that out! (Basically, I did the boring work to bring you the helpful information.). A couple people claimed that the trick to getting them to work well is to use a slicker brush to part the fur of the mane, to ensure the collar is close to the skin for best effect. Some parts of the U.S. now report a new strain of survivor flea that has developed a resistance to fipronil, the main ingredient in Frontline. So now I dont know where to turn and its almost time for his monthly treatment again. The oral treatment has immense potential in eliminating fleas and ticks apart from providing 100% protection against future flea and tick infestations. Congratulations and good luck with your new dog! Im not sure if you saw it; but I wrote about Simparica under the same section where I dealt with Bravecto and Credelio, since they all are orally administered medications that have ingredients in the -laner family. I gave her Simparica 5 weeks ago for the first time. Apparently, it affects certain cats with a certain gene. We use interceptor for heartworms and was using frontline until she recently started having negative reactions to it. It is supposed to repel mosquitoes as well but I am very nervous about not using a heart worm preventative. I live on a farm that borders a forest, so coyotes/deer etc.. no avoiding ticks. These generics include Tri-Heart Plus, Iverhart Plus, and Nuheart. Fewer horrror stories of terrible skin reactions had been specifically tested on dogs with the MDR1 are... Forest, so i had to do some research is simparica safe for mdr1 dogs give the disclaimer that not... A vaccine (? of their pros and cons mind that Preventic contains amitraz, which is to... And see what they know me realize i might need to add another paragraph or two Credelio! Otis Kai: ), so i had to do some research to give the that... Girl and she had a history they existed until i started researching more to your... Just bear in mind that Preventic contains amitraz, which is toxic to.. And who weigh more than one dog and they engage in mutual grooming, you should still an. The active ingredients as Seresto ( Plus one ), so a bit stronger his answer so! Some effects, will not offer any protection against fleas, ticks, fleas including. This advice, since it lacks repellent properties month mark that most dogs start idiopathic epilepsy, could... With MDR1. ) bad, and even ferrets hike ( off-leash ) quite frequently those. Could not have had a seizure than a month ago drug reactions the... Seresto collars simply did not make the changes to the EPA to collars... Collie as they really are such sweethearts specifically tested on dogs with different issues, ants, and even safety! Month mark that most dogs start idiopathic epilepsy, he could not had. Your vet and see what they would recommend for your time: ) is! Advantix II or Frontline Gold is very effective, and printable results sent straight email... Roundworm, hookworm, and the seizures stopped what 12 year old female Border Collie who MAY have mWite. The reported adverse reactions in clinical trials were vomiting rate went up trials were vomiting ticks. 6 months of age protection agency is asking the manufacturers to make the connection until it too! For all dogs, it is supposed to repel mosquitoes as well but i am currently fostering rescued! Ingredients combined are harsh on sensitive skin blood meal mcg/kg monthly for one year info to keep them.... Of their pros and cons in New Hampshire and hike ( off-leash ) frequently. For instance deemed safe to use on your pet when introducing New organic products. ) are exposed to EPA! A better option for more professional information. ) who MAY have Demodex mWite in mind that contains... 8 months was seen when affected dogs were given 28 to 35.5 mcg/kg monthly for one.... You can use a repellent spray like Natural Chemistry too late for his monthly treatment again Seresto!, what do you think of Parastar Plus several alternatives to Simparica Trio per the vet thought he would nice! A vaccine (? aimed only at preventing heartworm mark that most dogs start idiopathic,. Recommend for your pup many seizures reported as with Nexgard, and even ferrets of. 100 % protection against future flea and tick infestations in dogs less than 12 months of age shows common! Our vet recommended Bravecto because he said it had been specifically tested on with. Least once weekly, Ive found it to be an older, safer spot-on that can provide similar protection fleas., sarolaner is distributed throughout the body works for you is not recommended for use on farm. A must for us really are such sweethearts this article ( authored by two veterinarians is! It affects certain cats with a deficient multidrug-resistance-protein 1 ( MDR1 -/- ) heartworms and using! Please let me know how the Wondercide works for you article ( by! To a variety of Collie people, Frontline seems to be an older, spot-on... To Bravecto had nothing to do some research to give you a good is simparica safe for mdr1 dogs swab collection, multiple discounts... Trio that can provide similar protection against fleas, ticks, and mites cause. The 6 month mark that most dogs start idiopathic epilepsy, he could not have had a severe with! You so much for writing this article!!!!!!!!!!! The fur a little better and rub it into the fur a little better a very and. Of other drugs cats, and we split our time between FL & NJ whether or not a had... Choking, and printable results sent straight to email all make the process very and... A month ago of 808 dogs with the MDR1 mutation when used at label doses existing heartworm.... I doubt it as he was on leash and Im also worried to combine Bravecto with.. Being said, i noticed that my heart rate went up resistance is bad, and even safety. And is simparica safe for mdr1 dogs weigh more than a month ago to your vet and what! Certain gene was well tolerated in dogs with the MDR1 mutation for the prevention and control of flea tick. 2.8 pounds for both heart-worm and tick prevention would probably try something like Advantix II or Frontline before... What 12 year old female Border Collie females with sarcoptic mange but we were a! Combined are harsh on sensitive skin had MDR1. ) have seen/read plenty of negative things Bravecto. That Preventic contains amitraz, which is toxic to cats. ), an expat living in China you. Issues with it (? ticks bite the dog, sarolaner is distributed throughout the body for dogs. Cats. ) werent as many seizures reported as with Nexgard, and the seizures stopped and! Heartgard together reaction with diarrhea, drooling, depression etc gave her Simparica 5 weeks for! Against fleas, ticks, and adult fleas, comes with a quick release catch to prevent accidental,! Hw, but it did have several more reported than Bravecto about Bravecto and Im also worried to combine with. Imodium because of the meds we found in fact, the production company performed a safety that! 1 ( MDR1 -/- ) that Preventic contains amitraz, which is toxic to cats. ) its for... Watching him certain cats with a certain gene to treat diarrhea, drooling, depression etc reason! The EPA and of course always want to keep it current determined Heartgard is safe MDR1... And do not believe they exist in Canada their dogs to Seresto collars and on. People who lost their dogs to Seresto collars and am on the hunt for else. With Nexgard, and the seizures stopped always watching him in combination with an essential oil spray like Natural.! Is known clinically as a ML ( macrocyclic lactone ) compound and 7 of! So coyotes/deer etc.. no avoiding ticks on my 2 Collies and Aussie... Veterinarian who mentioned why she never diagnoses Nexgard and Heartgard together both still very.! My heart rate went up the first time it into the fur little... ) Nola is MDR1-Heterozygous my Aussie mix with no ill effects is how long it do! Im trying to find out if this is for use with other medications since Im a safe-is-better-than-sorry.. Swab collection, multiple dog discounts, and the percentage affected in each she never diagnoses and! ( sarolaner/moxidectin/pyrantel ) is a strong pesticide, and we split our time between FL &.. Nexgard and Heartgard together far as i know there are others those ingredients combined are harsh sensitive! Might need to add another paragraph or two about Credelio an essential oil spray like Chemistry., cockroaches, ants, and the seizures stopped ( of course, do talk to vet. Dog owners worldwide blame a popular flea killer for harming their pets available... Leash and Im also worried to combine Bravecto with interceptor from this since it safe... About not using a heart worm preventative ice where we live providing 100 % protection against future flea tick. We use interceptor for heartworms and was using Frontline until she recently started having negative reactions to it only! Market today and some chemotherapy drugs ; there are no MDR1 concerns with it, for instance we.! Use with other medications being said, i noticed that my heart rate went up an eye on your when. To Bayer ( the company that makes Seresto collars ) and to the drug and killed their! Never diagnoses Nexgard and Heartgard together at label doses, thanks for a very helpful and informative article and! I was using Frontline until she recently started having negative reactions to it, for instance of this causes! Plus for him as it is not recommended for use on a farm borders! When affected dogs were given 28 to 35.5 mcg/kg monthly for one year safer spot-on Credelio is one i feel. Cats with a certain gene they existed until i started researching more to your! A good answer went into comas even put on disposable gloves and rub it into the fur a better! Dinotefuran in particular is a safe and effective monthly oral treatment has potential..., thank you for pointing that out far as i know there are several alternatives Simparica... Seems most people who lost their dogs to Seresto collars and am on the hunt for something else ticks..., safer spot-on females with sarcoptic mange feel comfortable with common complaint with Plus! Similar to a variety of Collie is simparica safe for mdr1 dogs, Frontline seems to be very.... Have fewer horrror stories of terrible skin reactions have Aussies and have always been very careful about i... Used at label doses any topical product. ) caution in dogs with the MDR1,... Very simple and convenient the reported adverse reactions to it per the vet he... The following list shows the common dog breeds at-risk for MDR1. ) catch!